The Iverson FACTOR/MTHFR Panel is actually four tests in one. With a simple blood draw, you can identify four variants that increase the risk of thrombophilia* across three different genes:

Factor V Leiden

• The most common genetic risk factor for thrombophilia
• Present in 4 - 6% of US population1
• Heterozygote carriers have a 3-8 fold increased risk of VTE*2
• Homozygote carriers 30-140 fold increased risk of VTE2

Prothrombin (Factor II) G20210A

• G20210A* is the second most common hereditary risk factor for thrombophilia
• Heterozygotes have a three fold increase in the risk for VTE 3
• The heterozygous form of the mutation is present in 2.3% of the general population and 6.2% of patients with venous thrombosis, and 18% of cases of familial venous thrombosis.3,4

MTHFR

• MTHFR* is the key enzyme in homocysteine metabolism
• The C677T* variant is present in up to 44% of the population5
• The A1298C* variant is present 30% of the Caucasian population6
• A1298C in conjunction with C677T, has been associated with decreased MTHFR activity and elevated levels of homocysteine 7
• Hyperhomocysteinemia is a significant risk factor for cardiovascular disease 7
• There is a growing list of evidence linking MTHFR variants to other serious health conditions including recurrent pregnancy loss, neural tube defects, autism, mental health disorders and breast cancer
  

1. Grody W, Griffin J, Taylor A, Korf B, Heit, J. (2001) American College of Medical Genetics Consensus Statement on Factor V Leiden Mutation Testing, Genetics in Medicine, 3:2, 139-147.
2. Salomon O. et al; Single and Combined Prothrombotic Factors in Patients With Idiopathic Venous Thromboembolism; Arteriosclerosis Thrombosis and Vascular Biology, 1999, 19: 511-518
3. Van der Meer FJ, Koster T, Vandenbroucke JP, et al, "The Leiden Thrombophilia Study (LETS),"Thromb Haemost, 1997, 78(5):631-5.
4. Poort SR, Rosendaal FR, Reitsma PH, et al, "A Common Genetic Variation in the 3'-Untranslated Region of the Prothrombin Gene Is Associated With Elevated Plasma Prothrombin Levels and an Increase in Venous Thrombosis,"Blood, 1996, 88(10):3698-703.
5. Botto L, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 2000;151:862–877.
6. Langman LJ, Wong BYL, Boggis C, Rubin LA, Cole DEC (1998) The prevalence and linkage disequilibrium of three methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms varies in different ethnic groups. Paper presented at INABIS '98–5th Internet World Congress on Biomedical Sciences at McMaster University, Hamilton, Ontario, December 7–16.
7. Kolling K, Ndrepepa G, Koch W, Braun S, Mehilli J, Schomig A, Kastrati A. Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease. Am J Cardiol. 2004;10:1201–1206. doi: 10.1016/j.amjcard.2004.02.009.