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Minimize Adverse Drug Reactions
The vast majority of drugs are metabolized through the liver. The liver’s primary mechanism for metabolizing drugs is the P450 cytochrome system of enzymes which include CYP2D6, CYP2C9, and CYP2C19. Over 50% of the most commonly prescribed medications today are metabolized through the P450 System.
Not all patients respond appropriately to a standard, "One Size Fits All" dose. DNA testing provides a lifetime of protection against drug toxicity or lack of drug efficacy. This simple genetic test, which looks at liver enzymes, will determine your patient's drug sensitivity.
How a patient responds to medications depends on how well metabolizing enzymes function.
Why order the DME Genotype Panel (CYP2C9, CYP2D6, CYP2C19)?
- All enzymes are produced by specific genes that contain a DNA code for the construction of the enzyme.
- It is common for an enzyme’s DNA code to have an error. Typically this is caused by a single incorrect nucleotide in the DNA code. This error is referred to as a “Single Nucleotide Polymorphism” or “SNP” for short.
- A gene (allele) with a SNP is referred to as a “variant” gene (or “variant” allele).
- Over 50% (one of every two patients) will have a variant gene that alters the rate at which a drug-metabolizing enzyme functions.
- Variants usually result in enzymes having a significant loss-of-function (poor or intermediate metabolizers). In a few cases, a variant will create an enzyme with an unusually high rate of metabolism (ultra-rapid metabolizer).
- Patients with gene variants are 8 times more likely to experience an adverse drug reaction (toxicity or lack of efficacy) to their prescribed medications.
- Polypharmacy patients are at the greatest risk.
Will insurance pay for the DME Genotype Panel testing?
Medicare, Tricare and VA have shown insurance coverage acceptance for the cost of testing, if a physician feels it is medically necessary. The main reason for private insurance denials is that genetic testing is not a covered benefit; your patient can call their insurer to ask if this is a concern.
The Testing Process
The process is simple and conveniently done right in your office. We provide all the necessary test kits (either buccal swab or blood collection) supplies at "No Cost" to the provider.
- Easy-to-Read DNA Lab Test Results with useful drug interaction and dosing data
- All shipping supplies with prepaid return labels are included
- Test turnaround time: 24 hours delivered to you conveniently from our lab
- No "long-term" contracts necessary
How can I order the DME (Drug Metabolizing Enzymes) Genotype Panel for my patients?
Contact your Iverson Genetics local representative at (866) 900-0903 or email us at info@iversongenetics.com.
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Testing can be important for medications prescribed to treat even the most common conditions:
- Mental Health conditions
- Post MI Surgery
- Acid Reflux
- Cancer
- Organ Transplant
- Pregnancy
- Heart Failure
- High Blood Pressure
- Migraine Headaches
- Peptic Ulcer
- High Cholesterol
- Enlarged Prostate
- Asthma/COPD
- Depression
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Iverson's Lab Requisition form (pdf)
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